Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 12/20 | 0.52 |
| ▸ | NOS3 | P29474 | 11/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.44 |
| ▸ | NOS2 | P35228 | 5/20 | 0.42 |
| ▸ | EBP | Q15125 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6699624 | 0.90 | NOS1 (0.60) | NOS1NOS3CHRM2CHRM4ADRA1D | |
| SCHEMBL6699620 | 0.85 | NOS1 (0.52) | NOS1NOS3CHRM2CHRM4ADRA1D | |
| SCHEMBL6701981 | 0.83 | NOS1 (0.51) | NOS1NOS3CHRM2CHRM4ADRA1D | |
| SCHEMBL7583752 | 0.80 | NOS1 (0.48) | NOS1NOS3CHRM2CHRM4ADRA1D | |
| SCHEMBL7483828 | 0.79 | NOS1 (0.64) | NOS1NOS3CHRM2CHRM4EBP | |
| SCHEMBL6700030 | 0.79 | NOS1 (0.58) | NOS1NOS3CHRM2CHRM4NOS2 | |
| SCHEMBL6703642 | 0.78 | NOS1 (0.56) | NOS1NOS3CHRM2CHRM4NOS2 | |
| SCHEMBL6698798 | 0.77 | NOS1 (0.55) | NOS1NOS3CHRM2CHRM4NOS2 | |
| SCHEMBL7483824 | 0.77 | NOS1 (0.53) | NOS1NOS3CHRM2CHRM4ADRA1D | |
| SCHEMBL6702761 | 0.75 | NOS1 (0.60) | NOS1NOS3CHRM2CHRM4NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362195-B1 | INHIBITOR OF NITRIC OXIDE SYNTHASE; CENTRAL NERVOUS SYSTEM DISORDERS | PFIZER INC. | 2002-03-26 | — | — | US | disclosed |