Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7691943 | 0.94 | PARG (0.36) | PARGALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL194662 | 0.84 | USP2 (0.47) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL7983018 | 0.83 | USP2 (0.41) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL7966908 | 0.81 | MEN1 (0.38) | PARGALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL7685403 | 0.81 | NPC1 (0.36) | PARGALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL7670733 | 0.80 | ADORA1 (0.34) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2USP2 | |
| SCHEMBL7966922 | 0.78 | L3MBTL1 (0.38) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL7665277 | 0.78 | PARG (0.50) | PARGALDH1A1SMN1; SMN2 | |
| SCHEMBL7980691 | 0.77 | MAPK1 (0.40) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL7685590 | 0.74 | NPC1 (0.32) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441169-B1 | PHENYL, THIENYL (INCLUDING ALL 3 ISOMERS), THIAZOLYL OR PYRIDYL PYRIMIDINES; PROTECTING PLANTS AGAINST DISEASES CAUSED BY FUNGI, BACTERIA OR VIRUSES | SYNGENTA CROP PROTECTION, INC. | 2002-08-27 | — | — | US | claimed |
| CN-1269793-A | Pyrimidin-2-oxo-4-one and pyrimidin-2-oxo-4-thione derivatives | NOVARTIS AG (CH) | 2000-10-11 | — | — | CN | claimed |
| EP-1015435-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | Novartis AG (CH) | 2000-07-05 | — | — | EP | claimed |
| WO-1999011631-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | NOVARTIS AG (CH) | 1999-03-11 | — | — | WO | claimed |
| US-6441169-B1 | PHENYL, THIENYL (INCLUDING ALL 3 ISOMERS), THIAZOLYL OR PYRIDYL PYRIMIDINES; PROTECTING PLANTS AGAINST DISEASES CAUSED BY FUNGI, BACTERIA OR VIRUSES | SYNGENTA CROP PROTECTION, INC. | 2002-08-27 | — | — | US | disclosed |
| CN-1269793-A | Pyrimidin-2-oxo-4-one and pyrimidin-2-oxo-4-thione derivatives | NOVARTIS AG (CH) | 2000-10-11 | — | — | CN | disclosed |
| EP-1015435-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | Novartis AG (CH) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999011631-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | NOVARTIS AG (CH) | 1999-03-11 | — | — | WO | disclosed |