Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PNP | P00491 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30013461 | 1.00 | POLA1 (0.62) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL766453 | 1.00 | POLA1 (0.62) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL6280165 | 0.91 | POLA1 (0.65) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL264546 | 0.86 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL264545 | 0.86 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL25507075 | 0.86 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL12714741 | 0.86 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL20346237 | 0.86 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL10068104 | 0.86 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL890293 | 0.86 | POLA1 (0.66) | POLA1KDM4EPNPLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11835499-B2 | Methods of quantifying methylglyoxal-induced nucleic acid adducts | CITY OF HOPE (US) | 2023-12-05 | — | — | US | disclosed |
| US-11835499-B2 | Methods of quantifying methylglyoxal-induced nucleic acid adducts | CITY OF HOPE (US) | 2023-12-05 | — | — | US | disclosed |
| US-20220331273-A1 | METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEDG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEDG | CITY OF HOPE (US) | 2022-10-20 | — | — | US | disclosed |
| US-20220331273-A1 | METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEDG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEDG | CITY OF HOPE (US) | 2022-10-20 | — | — | US | disclosed |
| US-11266618-B2 | Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG | CITY OF HOPE (US) | 2022-03-08 | — | — | US | disclosed |
| US-11179361-B2 | Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG | CITY OF HOPE (US) | 2021-11-23 | — | — | US | disclosed |
| US-20200363381-A1 | METHODS OF QUANTIFYING METHYLGLYOXAL-INDUCED NUCLEIC ACID ADDUCTS | CITY OF HOPE (US) | 2020-11-19 | — | — | US | disclosed |
| WO-2019152728-A1 | METHODS OF QUANTIFYING METHYLGLYOXAL-INDUCED NUCLEIC ACID ADDUCTS | CITY OF HOPE (US) | 2019-08-08 | — | — | WO | disclosed |
| US-20180338939-A1 | METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEDG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEDG | CITY OF HOPE | 2018-11-29 | — | — | US | disclosed |
| US-20180207116-A1 | METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEDG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEDG | CITY OF HOPE | 2018-07-26 | — | — | US | disclosed |
| US-9855233-B2 | Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG | CITY OF HOPE (US) | 2018-01-02 | — | — | US | disclosed |
| US-20150290156-A1 | METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEDG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEDG | CITY OF HOPE | 2015-10-15 | — | — | US | disclosed |
| US-20120071559-A1 | METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEdG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEdG | RAHBAR SAMUEL (US) | 2012-03-22 | — | — | US | disclosed |
| US-20100102218-A1 | METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEdG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEdG | CITY OF HOPE | 2010-04-29 | — | — | US | disclosed |