Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GCK | P35557 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8333919 | 0.88 | GPR119 (0.54) | NAMPTGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL7670250 | 0.88 | NAMPT (0.54) | NAMPTGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL7673219 | 0.87 | NAMPT (0.53) | NAMPTGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL6608352 | 0.85 | NAMPT (0.51) | NAMPTGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL6326316 | 0.83 | GPR119 (0.46) | NAMPTGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL4682170 | 0.82 | KDM4E (0.45) | NAMPTGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL7667732 | 0.81 | NAMPT (0.48) | NAMPTGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL4675927 | 0.81 | GPR119 (0.50) | NAMPTGPR119KDM4EPKMSTS | |
| SCHEMBL3436365 | 0.80 | GPR119 (0.58) | NAMPTGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL1475943 | 0.79 | EPHX2 (0.51) | GPR119PTPN2PTPN1PTPN6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365602-B1 | FOR THERAPY OF DEPRESSION, ANXIETY, ASTHMA, PAIN, INFLAMMATION, URINARY INCONTINENCE AND OTHER DISEASE CONDITIONS | ASTRA ZENECA AB (SE) | 2002-04-02 | — | — | US | disclosed |
| EP-1097137-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002859-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |