Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.69 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | FPR2 | P25090 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16835041 | 0.89 | NAMPT (0.67) | NAMPTPTPN2PTPN1PTPN6CA12 | |
| SCHEMBL10127488 | 0.88 | NAMPT (0.71) | NAMPTPTPN2PTPN1PTPN6CA12 | |
| SCHEMBL6917548 | 0.87 | NAMPT (0.67) | NAMPTPTPN2PTPN1PTPN6ABL1 | |
| SCHEMBL15587463 | 0.87 | NAMPT (0.65) | NAMPTPTPN2PTPN1PTPN6CA12 | |
| SCHEMBL5664016 | 0.84 | NAMPT (0.67) | NAMPTPTPN2PTPN1PTPN6CA12 | |
| SCHEMBL5466754 | 0.84 | NAMPT (0.61) | NAMPTPTPN2PTPN1PTPN6CA12 | |
| SCHEMBL27091797 | 0.84 | NAMPT (0.61) | NAMPTPTPN2PTPN1PTPN6CA12 | |
| SCHEMBL20354696 | 0.84 | NAMPT (0.66) | NAMPTPTPN2PTPN1PTPN6CA12 | |
| SCHEMBL21965379 | 0.84 | NAMPT (0.66) | NAMPTPTPN2PTPN1PTPN6ABL1 | |
| SCHEMBL5458069 | 0.82 | NAMPT (0.65) | NAMPTPTPN2PTPN1PTPN6CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365602-B1 | FOR THERAPY OF DEPRESSION, ANXIETY, ASTHMA, PAIN, INFLAMMATION, URINARY INCONTINENCE AND OTHER DISEASE CONDITIONS | ASTRA ZENECA AB (SE) | 2002-04-02 | — | — | US | disclosed |
| EP-1097137-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002859-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |