Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.65 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 4/20 | 0.50 |
| ▸ | JAK3 | P52333 | 4/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5456870 | 0.87 | NAMPT (0.64) | NAMPTPTPN2PTPN1PTPN6JAK2 | |
| SCHEMBL5455925 | 0.84 | NPC1 (0.56) | NAMPTJAK3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5457840 | 0.83 | NAMPT (0.62) | NAMPTJAK2JAK3NPC1RAB9A | |
| SCHEMBL7667693 | 0.82 | NAMPT (0.69) | NAMPTPTPN2PTPN1PTPN6JAK2 | |
| SCHEMBL161991 | 0.82 | DGAT1 (0.51) | NAMPTPTPN2PTPN1PTPN6JAK2 | |
| SCHEMBL1989165 | 0.82 | NAMPT (0.65) | NAMPTPTPN2PTPN1PTPN6JAK3 | |
| SCHEMBL1989164 | 0.82 | NAMPT (0.65) | NAMPTPTPN2PTPN1PTPN6JAK3 | |
| SCHEMBL16835041 | 0.82 | NAMPT (0.67) | NAMPTPTPN2PTPN1PTPN6JAK2 | |
| SCHEMBL13060443 | 0.80 | PTPN2 (0.62) | PTPN2PTPN1PTPN6NPC1RAB9A | |
| SCHEMBL10127488 | 0.80 | NAMPT (0.71) | NAMPTPTPN2PTPN1PTPN6JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249620-A1 | Urea Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-10-25 | — | — | US | disclosed |
| EP-1764360-A1 | UREA DERIVATIVE | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249620-A1 | Urea Derivative | UGP2, SLC14A1, DGAT1 | NAMPT 324/4885PTPN2 3468/4885PTPN1 3460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.