Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656655 | 0.91 | POLB (0.97) | POLBCYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL7504156 | 0.89 | POLB (0.93) | POLBCYP1A2CYP2D6CYP2C19CYP2C9 | |
| Hydrochloric Acid SCHEMBL3851668 | 0.89 | POLB (1.00) | POLBCYP1A2CYP2D6CYP2C19CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL18050103 | 0.86 | KMT2A (0.59) | POLBCYP1A2CYP2D6CYP2C19CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL7669178 | 0.86 | POLB (0.58) | POLBCYP1A2CYP2D6CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL7670169 | 0.86 | POLB (0.59) | POLBCYP1A2CYP2D6FAAH | |
| SCHEMBL2027079 | 0.85 | POLB (0.85) | POLBCYP1A2CYP2D6CYP2C19CYP2C9 | |
| Pyridine SCHEMBL28096189 | 0.82 | POLB (0.80) | POLBCYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL7320026 | 0.82 | POLB (0.79) | POLBCYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL5585873 | 0.81 | POLB (0.79) | POLBCYP1A2CYP2D6CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355641-B1 | HYPOTENSIVE AGENTS AND WOUND HEALING AGENTS | SYNTEX (U.S.A.) LLC | 2002-03-12 | — | — | US | disclosed |
| WO-2000055143-A1 | OXAZOLONE DERIVATIVES AND THEIR USE AS ALPHA-1 ADRENORECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-09-21 | — | — | WO | disclosed |