Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
| ▸ | FAAH | O00519 | 6/20 | 0.48 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30791537 | 0.91 | POLB (0.66) | POLBTRPV1CYP2D6CYP1A2GRIN2B | |
| SCHEMBL1758868 | 0.91 | POLB (0.66) | POLBTRPV1CYP2D6CYP1A2GRIN2B | |
| Hydrochloric Acid SCHEMBL2194067 | 0.90 | POLB (0.68) | POLBTRPV1CYP2D6CYP1A2GRIN2B | |
| Trifluoroacetic Acid SCHEMBL7659069 | 0.88 | MKNK1 (0.46) | POLBTRPV1GRIN2BFAAHHTR2C | |
| Trifluoroacetic Acid SCHEMBL7667828 | 0.86 | POLB (0.80) | POLBCYP2D6CYP1A2FAAH | |
| Pyridine SCHEMBL28096189 | 0.80 | POLB (0.80) | POLBCYP2D6CYP1A2FAAH | |
| SCHEMBL3768246 | 0.79 | TRPV1 (0.60) | TRPV1CYP2D6GRIN2BFAAHHTR2C | |
| SCHEMBL15529643 | 0.79 | TRPV1 (0.60) | TRPV1GRIN2BFAAHHTR2CHTR2A | |
| SCHEMBL1960679 | 0.77 | TRPV1 (0.58) | POLBTRPV1GRIN2BFAAHHTR2C | |
| SCHEMBL656655 | 0.77 | POLB (0.97) | POLBCYP2D6CYP1A2FAAHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355641-B1 | HYPOTENSIVE AGENTS AND WOUND HEALING AGENTS | SYNTEX (U.S.A.) LLC | 2002-03-12 | — | — | US | disclosed |
| WO-2000055143-A1 | OXAZOLONE DERIVATIVES AND THEIR USE AS ALPHA-1 ADRENORECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-09-21 | — | — | WO | disclosed |