Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665849 | 0.83 | HSD17B10 (0.43) | HSD17B10ALPLALDH1A1GABRA1GABRG2 | |
| SCHEMBL7665905 | 0.81 | HPGD (0.49) | ALPLALDH1A1LRRK2HPGDCYP3A4 | |
| SCHEMBL3629414 | 0.78 | HSD17B10 (0.51) | HSD17B10ALPLALDH1A1GABRA1GABRG2 | |
| SCHEMBL1220108 | 0.74 | HSD17B10 (0.42) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL7663410 | 0.72 | HSD17B10 (0.41) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL7661033 | 0.70 | HSD17B10 (0.40) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL3630522 | 0.69 | BUB1 (0.40) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL7672484 | 0.69 | HSD17B10 (0.39) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL6767802 | 0.69 | ALPL (0.39) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL5417695 | 0.67 | AURKA (0.41) | HSD17B10ALPLALDH1A1HPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395766-B1 | COGNITION ACTIVATORS | MERCK SHARP & DOHME LIMITED (GB) | 2002-05-28 | — | — | US | disclosed |