Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | BAD | Q92934 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | BRS3 | P32247 | 2/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668198 | 1.00 | BCL2L1 (0.38) | BCL2L1BADNAMPTCYP19A1BRS3 | |
| SCHEMBL7672140 | 0.88 | SLC6A4 (0.43) | NAMPTCYP3A4 | |
| SCHEMBL7672136 | 0.88 | SLC6A4 (0.43) | NAMPTCYP3A4 | |
| SCHEMBL7856346 | 0.81 | BRS3 (0.43) | BCL2L1BADBRS3 | |
| SCHEMBL7667604 | 0.81 | FNTA (0.58) | FNTAFNTB | |
| SCHEMBL7667593 | 0.81 | FNTA (0.58) | FNTAFNTB | |
| SCHEMBL7668332 | 0.79 | BCL2L1 (0.38) | BCL2L1BADNAMPTBRS3GSK3B | |
| SCHEMBL7668328 | 0.79 | BCL2L1 (0.38) | BCL2L1BADNAMPTBRS3GSK3B | |
| SCHEMBL7667006 | 0.77 | NAMPT (0.39) | BCL2L1BADNAMPTBRS3GSK3B | |
| SCHEMBL7667000 | 0.77 | NAMPT (0.39) | BCL2L1BADNAMPTBRS3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486156-B1 | Chemical compounds | ASTRAZENECA AB (SE) | 2002-11-26 | — | — | US | disclosed |
| EP-1140858-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039716-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |