Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TLR4 | O00206 | 2/20 | 0.52 |
| ▸ | TLR2 | O60603 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | FOS | P01100 | 1/20 | 0.45 |
| ▸ | JUN | P05412 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28397202 | 0.87 | KDM4E (0.78) | KDM4EALDH1A1SMN1; SMN2KMT2ATLR4 | |
| SCHEMBL28397201 | 0.87 | KDM4E (0.78) | KDM4EALDH1A1SMN1; SMN2KMT2ATLR4 | |
| SCHEMBL19244306 | 0.84 | APP (0.60) | KDM4EALDH1A1SMN1; SMN2KMT2ATLR4 | |
| SCHEMBL19244235 | 0.84 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2KMT2ATLR4 | |
| SCHEMBL10021693 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2KMT2ATLR4 | |
| SCHEMBL7222274 | 0.83 | KDM4E (0.60) | KDM4EALDH1A1SMN1; SMN2KMT2ATLR4 | |
| SCHEMBL7222278 | 0.83 | KDM4E (0.60) | KDM4EALDH1A1SMN1; SMN2KMT2ATLR4 | |
| SCHEMBL7054652 | 0.82 | ABCG2 (0.63) | KDM4EALDH1A1SMN1; SMN2KMT2AABCG2 | |
| SCHEMBL7054651 | 0.82 | ABCG2 (0.63) | KDM4EALDH1A1SMN1; SMN2KMT2AABCG2 | |
| SCHEMBL19244368 | 0.81 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2KMT2ATLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441173-B1 | NOVEL INTERMEDIATES OF AND CONVERSION TO 3-(2-(2-HYDROXYETH-1-YLOXY) OR (2-CARBOXYMETHOXY)-4-METHOXYPHENYL)-1-(3,4-METHYLENE DIOXYPHENYL)-5-(PROP-1-YLOXY)INDANE-2-CARBOXYLIC ACID | SMITHKLINE BEECHAM CORPORATION | 2002-08-27 | — | — | US | disclosed |
| EP-0876352-A4 | PROCESS | SMITHKLINE BEECHAM CORP (US) | 2001-11-14 | — | — | EP | disclosed |
| US-6114549-A | Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0876352-A1 | PROCESS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997017330-A1 | PROCESS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-15 | — | — | WO | disclosed |