Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.36 |
| ▸ | CDK2 | P24941 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666287 | 0.89 | PDGFRA (0.41) | NR3C1PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7668358 | 0.88 | CCNE1 (0.39) | NR3C1PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7670257 | 0.86 | PDGFRA (0.38) | NR3C1PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7674135 | 0.85 | PDGFRA (0.43) | JAK2NR3C1PDGFRACCNE1CDK2 | |
| SCHEMBL7365457 | 0.84 | PDGFRA (0.39) | NR3C1PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7661658 | 0.84 | PDGFRA (0.38) | NR3C1PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7356565 | 0.84 | PDGFRA (0.38) | NR3C1PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7661594 | 0.84 | CDK2 (0.43) | JAK2PDGFRACCNE1CDK2HDAC1 | |
| SCHEMBL7670268 | 0.83 | CDK2 (0.38) | NR3C1PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7668529 | 0.83 | PDGFRA (0.38) | NR3C1PDGFRACCNE1CDK2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |