Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 9/20 | 0.51 |
| ▸ | TACR1 | P25103 | 5/20 | 0.51 |
| ▸ | TACR3 | P29371 | 5/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | HAT1 | O14929 | 3/20 | 0.31 |
| ▸ | EP300 | Q09472 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255229 | 0.89 | TACR2 (0.52) | TACR2TACR1TACR3MCHR1XDH | |
| SCHEMBL7666225 | 0.89 | TACR2 (0.54) | TACR2TACR1TACR3MCHR1XDH | |
| SCHEMBL7669440 | 0.88 | TACR2 (0.47) | TACR2TACR1TACR3MCHR1XDH | |
| SCHEMBL756430 | 0.87 | TACR2 (0.64) | TACR2TACR1TACR3 | |
| SCHEMBL6668994 | 0.87 | TACR2 (0.64) | TACR2TACR1TACR3 | |
| SCHEMBL6002422 | 0.84 | TACR2 (0.48) | TACR2TACR1TACR3MCHR1CA1 | |
| SCHEMBL6002594 | 0.84 | TACR2 (0.48) | TACR2TACR1TACR3XDHSLC22A12 | |
| SCHEMBL7668781 | 0.83 | CNR2 (0.38) | TACR2TACR1TACR3 | |
| SCHEMBL3226464 | 0.79 | TACR2 (0.46) | TACR2TACR1TACR3MCHR1XDH | |
| SCHEMBL4260104 | 0.79 | TACR2 (0.46) | TACR2TACR1TACR3MCHR1XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365602-B1 | FOR THERAPY OF DEPRESSION, ANXIETY, ASTHMA, PAIN, INFLAMMATION, URINARY INCONTINENCE AND OTHER DISEASE CONDITIONS | ASTRA ZENECA AB (SE) | 2002-04-02 | — | — | US | disclosed |
| EP-1097137-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002859-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |