Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | TXK | P42681 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674611 | 0.93 | HDAC1 (0.43) | HDAC1HDAC8F2ALDH1A1THRB | |
| SCHEMBL7664586 | 0.92 | F2 (0.52) | HDAC1HDAC8F2ALDH1A1 | |
| SCHEMBL7664504 | 0.90 | F2 (0.43) | HDAC1HDAC8F2ALDH1A1CNR2 | |
| SCHEMBL7664507 | 0.89 | HDAC1 (0.46) | HDAC1HDAC8F2ALDH1A1CNR2 | |
| SCHEMBL7675369 | 0.86 | F2 (0.41) | HDAC1HDAC8F2ALDH1A1CNR2 | |
| SCHEMBL7670944 | 0.85 | F2 (0.40) | HDAC1HDAC8F2CNR2NOS1 | |
| SCHEMBL7672300 | 0.85 | HDAC1 (0.42) | HDAC1HDAC8F2ALDH1A1CNR2 | |
| SCHEMBL7671039 | 0.85 | F2 (0.53) | HDAC1HDAC8F2THRBRECQL | |
| SCHEMBL7667594 | 0.82 | F2 (0.55) | HDAC1HDAC8F2CNR2 | |
| SCHEMBL7668863 | 0.82 | F2 (0.55) | HDAC1HDAC8F2THRBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365584-B1 | FOR PROPHYLAXIS AND THERAPY OF INFLAMMATORY AND/OR ALLERGIC DISEASES, LUNG FIBROSIS, FIBROSING ALVEOLITIS AND SCARRING, COLLAGENOSES SUCH AS LUPUS ERYTHEMATODES AND SCLERODERMIA AS WELL AS ARTERIOSCLEROSIS, PSORIASIS AND NEOPLASM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-04-02 | — | — | US | disclosed |