Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.38 |
| ▸ | NOS1 | P29475 | 4/20 | 0.38 |
| ▸ | NOS3 | P29474 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672536 | 0.92 | F2 (0.49) | F2HDAC1HDAC8LMNAMAPK1 | |
| SCHEMBL7664504 | 0.89 | F2 (0.43) | F2HDAC1HDAC8OPRM1NOS1 | |
| SCHEMBL7664507 | 0.88 | HDAC1 (0.46) | F2HDAC1HDAC8OPRM1NOS1 | |
| SCHEMBL7674611 | 0.88 | HDAC1 (0.43) | F2HDAC1HDAC8 | |
| SCHEMBL7669133 | 0.85 | HDAC1 (0.43) | F2HDAC1HDAC8OPRM1NOS1 | |
| SCHEMBL7675369 | 0.85 | F2 (0.41) | F2HDAC1HDAC8OPRM1NOS1 | |
| SCHEMBL6983580 | 0.84 | F2 (0.52) | F2HDAC1HDAC8CNR2 | |
| SCHEMBL7672300 | 0.84 | HDAC1 (0.42) | F2HDAC1HDAC8OPRM1NOS1 | |
| SCHEMBL6974208 | 0.82 | BMP1 (0.45) | F2OPRM1NOS1NOS3CNR2 | |
| SCHEMBL7667594 | 0.81 | F2 (0.55) | F2HDAC1HDAC8LMNACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365584-B1 | FOR PROPHYLAXIS AND THERAPY OF INFLAMMATORY AND/OR ALLERGIC DISEASES, LUNG FIBROSIS, FIBROSING ALVEOLITIS AND SCARRING, COLLAGENOSES SUCH AS LUPUS ERYTHEMATODES AND SCLERODERMIA AS WELL AS ARTERIOSCLEROSIS, PSORIASIS AND NEOPLASM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-04-02 | — | — | US | disclosed |