SCHEMBL7669240

SCHEMBL7669240

CNC(=S)N(C)Cc1cscn1

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 2/20 0.36
NR1H3 Q13133 2/20 0.36
SLC6A3 Q01959 4/20 0.33
LMNA P02545 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
MAPK1 P28482 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
KDM4C Q9H3R0 1/20 0.31
ALDH1A1 P00352 2/20 0.31
CTH P32929 1/20 0.31
TSHR P16473 1/20 0.31
CYP3A4 P08684 2/20 0.30
GAA P10253 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
PKM P14618 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27296569 0.80 NR1H2 (0.38) NR1H2NR1H3SLC6A3LMNAMAPK1
SCHEMBL9369569 0.73
SCHEMBL7657928 0.71 SMN1; SMN2 (0.40) CYP3A4SMN1; SMN2
SCHEMBL7660360 0.71 MEN1 (0.49) LMNANPSR1ALDH1A1SMN1; SMN2
SCHEMBL15490025 0.69 CYP3A4 (0.36) NR1H2NR1H3SLC6A3LMNAMAPK1
SCHEMBL7662771 0.69 NR1H2 (0.38) NR1H2NR1H3LMNAMAPK1NPSR1
SCHEMBL2736260 0.67 CYP3A4 (0.49) NPSR1CYP3A4
SCHEMBL7670376 0.67 KMT2A (0.36) SLC6A3LMNAL3MBTL1ALDH1A1GAA
SCHEMBL12888691 0.66 NR1H2 (0.37) NR1H2NR1H3SLC6A3LMNAMAPK1
SCHEMBL23118696 0.66 MAPK1 (0.47) SLC6A3LMNAMAPK1NPSR1KDM4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6407248-B1 INSECTICIDES, MITICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-06-18 US disclosed
US-6124297-A COMBATTING INSECTS OR MITES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-09-26 US disclosed
US-5935981-A INSECTICIDAL/MITICIDAL ACTIVITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-08-10 US disclosed
US-5849768-A α-unsaturated amines, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-12-15 US disclosed
EP-0529680-B1 Intermediates, their production and their use for preparing alpha-unsaturated amines TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-05-13 EP disclosed
EP-0302389-B1 Alpha-unsaturated amines, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1993-12-22 EP disclosed
US-5214152-A Insecticides, miticides TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-05-25 US disclosed
EP-0529680-A2 Intermediates, their production and their use for preparing alpha-unsaturated amines TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-03-03 EP disclosed
US-5175301-A Insecticide, miticide, pesticide TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-12-29 US disclosed
EP-0509559-A2 Alpha-unsaturated amines, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-10-21 EP disclosed
EP-0302389-A2 Alpha-unsaturated amines, their production and use Takeda Chemical Industries, Ltd. (JP) 1989-02-08 EP disclosed