SCHEMBL7660360

SCHEMBL7660360

CNC(=S)N(C)Cc1ccccn1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
SMN1; SMN2 Q16637 3/20 0.47
MAPT P10636 2/20 0.47
LIN28A Q9H9Z2 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
ALDH1A1 P00352 5/20 0.46
NPSR1 Q6W5P4 3/20 0.46
HTT P42858 1/20 0.46
LMNA P02545 2/20 0.45
POLB P06746 1/20 0.45
HRH3 Q9Y5N1 1/20 0.45
HSP90AA1 P07900 1/20 0.44
RAB9A P51151 1/20 0.44
HKDC1 Q2TB90 1/20 0.44
TAAR1 Q96RJ0 1/20 0.44
ALOX15 P16050 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9259765 0.80 SMN1; SMN2 (0.50) MEN1KMT2ASMN1; SMN2MAPTLIN28A
SCHEMBL7657928 0.77 SMN1; SMN2 (0.40) MEN1KMT2ASMN1; SMN2TDP1POLB
SCHEMBL7332427 0.77 CA2 (0.53) MEN1KMT2ASMN1; SMN2MAPTALDH1A1
SCHEMBL11643855 0.76 ALDH1A1 (0.54) MEN1KMT2ASMN1; SMN2MAPTALDH1A1
SCHEMBL7333583 0.75 CA2 (0.49) SMN1; SMN2ALDH1A1LMNAPOLB
SCHEMBL427048 0.75 SMN1; SMN2 (0.52) KMT2ASMN1; SMN2MAPTLIN28ATDP1
SCHEMBL6204342 0.75 KDM4E (0.52) KMT2ASMN1; SMN2MAPTLIN28ATDP1
SCHEMBL676887 0.74 SMN1; SMN2 (0.47) MEN1KMT2ASMN1; SMN2MAPTLIN28A
SCHEMBL11528266 0.74 CA12 (0.59) MEN1KMT2ASMN1; SMN2ALDH1A1LMNA
SCHEMBL11642877 0.74 ALDH1A1 (0.56) MEN1KMT2ASMN1; SMN2MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6407248-B1 INSECTICIDES, MITICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-06-18 US disclosed
US-6124297-A COMBATTING INSECTS OR MITES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-09-26 US disclosed
US-5935981-A INSECTICIDAL/MITICIDAL ACTIVITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-08-10 US disclosed
US-5849768-A α-unsaturated amines, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-12-15 US disclosed
EP-0529680-B1 Intermediates, their production and their use for preparing alpha-unsaturated amines TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-05-13 EP disclosed
EP-0302389-B1 Alpha-unsaturated amines, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1993-12-22 EP disclosed
US-5214152-A Insecticides, miticides TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-05-25 US disclosed
EP-0529680-A2 Intermediates, their production and their use for preparing alpha-unsaturated amines TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-03-03 EP disclosed
US-5175301-A Insecticide, miticide, pesticide TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-12-29 US disclosed
EP-0509559-A2 Alpha-unsaturated amines, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-10-21 EP disclosed
EP-0302389-A2 Alpha-unsaturated amines, their production and use Takeda Chemical Industries, Ltd. (JP) 1989-02-08 EP disclosed