Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MPL | P40238 | 1/20 | 0.40 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1072127 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDNPSR1MEN1 | |
| SCHEMBL1518494 | 0.79 | KDM4E (0.47) | ALDH1A1KDM4EHPGDNPSR1MEN1 | |
| SCHEMBL1518492 | 0.79 | KDM4E (0.47) | ALDH1A1KDM4EHPGDNPSR1MEN1 | |
| SCHEMBL5364915 | 0.78 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDNPSR1MEN1 | |
| SCHEMBL15936293 | 0.78 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDNPSR1MEN1 | |
| SCHEMBL5315678 | 0.78 | KDM4E (0.58) | ALDH1A1KDM4EHPGDNPSR1MEN1 | |
| SCHEMBL1539120 | 0.77 | ALDH1A1 (0.66) | ALDH1A1KDM4EHPGDNPSR1MEN1 | |
| SCHEMBL10120354 | 0.76 | KDM4E (0.56) | ALDH1A1KDM4EHPGDNPSR1MEN1 | |
| SCHEMBL2152502 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDNPSR1MEN1 | |
| SCHEMBL14499346 | 0.76 | KDM4E (0.56) | ALDH1A1KDM4EHPGDNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365602-B1 | FOR THERAPY OF DEPRESSION, ANXIETY, ASTHMA, PAIN, INFLAMMATION, URINARY INCONTINENCE AND OTHER DISEASE CONDITIONS | ASTRA ZENECA AB (SE) | 2002-04-02 | — | — | US | disclosed |
| EP-1097137-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002859-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |