Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246880 | 0.86 | TSHR (0.55) | TSHREPHX2ALDH1A1LMNACA12 | |
| SCHEMBL4692794 | 0.82 | CYP1A2 (0.52) | EPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL21538522 | 0.80 | TSHR (0.61) | TSHREPHX2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL407248 | 0.80 | TSHR (0.61) | TSHREPHX2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28333574 | 0.79 | TSHR (0.75) | TSHREPHX2ALDH1A1LMNACA12 | |
| SCHEMBL15044413 | 0.78 | TSHR (0.58) | TSHREPHX2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL26478859 | 0.78 | ZDHHC20 (0.56) | TSHREPHX2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9863497 | 0.77 | TSHR (0.64) | TSHREPHX2ALDH1A1LMNARECQL | |
| SCHEMBL16620817 | 0.77 | RECQL (0.61) | TSHREPHX2ALDH1A1LMNARECQL | |
| SCHEMBL19934140 | 0.77 | MEN1 (0.64) | TSHREPHX2ALDH1A1SMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355640-B1 | TREATMENT OF HYPERTENSION, UROGENITAL DISORDERS AND FORMED BY WITTIG REACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-12 | — | — | US | disclosed |
| US-5773530-A | USEFUL AS PSYCHOSTIMULANTS, ANTIHYPERTENSIVE AGENTS AND REMEDIES FOR RENAL FAILURE, DIURETICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| EP-0737193-A1 | PYRAZOLOPYRIDINE ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-16 | — | — | EP | disclosed |
| WO-1995018128-A1 | PYRAZOLOPYRIDINE ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-06 | — | — | WO | disclosed |