Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.72 |
| ▸ | DRD2 | P14416 | 3/20 | 0.72 |
| ▸ | HRH1 | P35367 | 4/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.71 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.71 |
| ▸ | USP2 | O75604 | 3/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.71 |
| ▸ | HRH2 | P25021 | 2/20 | 0.71 |
| ▸ | HTR2A | P28223 | 2/20 | 0.71 |
| ▸ | HTR2B | P41595 | 2/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.71 |
| ▸ | DRD4 | P21917 | 1/20 | 0.71 |
| ▸ | HTR7 | P34969 | 1/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.71 |
| ▸ | HTR5A | P47898 | 1/20 | 0.71 |
| ▸ | HTR6 | P50406 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10503557 | 0.97 | DRD3 (0.69) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL16769338 | 0.91 | DRD3 (0.67) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL27340092 | 0.91 | DRD3 (0.66) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL9253472 | 0.91 | DRD3 (0.66) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL16769339 | 0.91 | DRD3 (0.67) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL20329228 | 0.90 | DRD3 (0.68) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL16769451 | 0.89 | DRD3 (0.72) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL13302837 | 0.89 | DRD3 (0.72) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL16769330 | 0.89 | DRD3 (0.72) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL4246056 | 0.88 | DRD3 (0.66) | DRD3DRD2HRH1KCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420560-B1 | BINDING COMPOUND AS ANTIHISTAMINES AND ANTIALLERGENS | THERAVANCE, INC. | 2002-07-16 | — | — | US | disclosed |
| EP-1085868-A1 | H1-HISTAMINE RECEPTOR ANTAGONISTS | Advanced Medicine, Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999063999-A1 | H1-HISTAMINE RECEPTOR ANTAGONISTS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |