Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.66 |
| ▸ | DRD2 | P14416 | 4/20 | 0.66 |
| ▸ | HRH1 | P35367 | 4/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | HRH2 | P25021 | 2/20 | 0.65 |
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | HTR2B | P41595 | 2/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | DRD4 | P21917 | 1/20 | 0.65 |
| ▸ | HTR7 | P34969 | 1/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.65 |
| ▸ | HTR5A | P47898 | 1/20 | 0.65 |
| ▸ | HTR6 | P50406 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20329228 | 0.96 | DRD3 (0.68) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL4246056 | 0.92 | DRD3 (0.66) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL7670965 | 0.91 | DRD3 (0.72) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL4249527 | 0.91 | DRD3 (0.61) | DRD3DRD2HRH1KCNH2CHRM2 | |
| Hydrochloric Acid SCHEMBL10503557 | 0.89 | DRD3 (0.69) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL16757158 | 0.87 | DRD3 (0.78) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL12324774 | 0.87 | DRD3 (0.78) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL3631349 | 0.87 | DRD2 (0.63) | DRD3DRD2LMNA | |
| SCHEMBL16769339 | 0.86 | DRD3 (0.67) | DRD3DRD2HRH1KCNH2CHRM2 | |
| SCHEMBL16769338 | 0.86 | DRD3 (0.67) | DRD3DRD2HRH1KCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470851-A | Antihistamine, anticoagulants | SANKYO COMPANY, LIMITED (JP) | 1995-11-28 | — | — | US | disclosed |
| CN-1058780-A | Has the active thiazolidine carboxylic acid amides derivative of anti-allergy, their preparation and application | SANKYO CO (JP) | 1992-02-19 | — | — | CN | disclosed |
| EP-0463873-A1 | Thiazolidinecarboxylic acid amide derivatives having anti-allergic activity, their preparation and their use | Sankyo Company Limited (JP) | 1992-01-02 | — | — | EP | disclosed |
| US-4591590-A | ANTIALLERGINS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-27 | — | — | US | disclosed |
| EP-0113226-A1 | Benzhydrylpiperazine derivatives, processes for the preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-11 | — | — | EP | disclosed |