Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.35 |
| ▸ | ITGAV | P06756 | 12/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.33 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670998 | 1.00 | ITGB3 (0.35) | ITGB3ITGAVITGB1ITGA2BITGA5 | |
| SCHEMBL7197024 | 0.87 | ITGB3 (0.39) | ITGB3ITGAVITGB1ITGA2BITGA5 | |
| SCHEMBL7197018 | 0.87 | ITGB3 (0.39) | ITGB3ITGAVITGB1ITGA2BITGA5 | |
| SCHEMBL7677699 | 0.77 | ITGAV (0.61) | ITGB3ITGAVITGB1ITGA2BITGA5 | |
| SCHEMBL7680084 | 0.77 | ITGAV (0.61) | ITGB3ITGAVITGB1ITGA2BITGA5 | |
| SCHEMBL7677703 | 0.77 | ITGAV (0.61) | ITGB3ITGAVITGB1ITGA2BITGA5 | |
| SCHEMBL7677494 | 0.71 | ITGAV (0.70) | ITGB3ITGAVITGB1ITGA2BITGA5 | |
| SCHEMBL7677496 | 0.71 | ITGAV (0.70) | ITGB3ITGAVITGB1ITGA2BITGA5 | |
| SCHEMBL20140389 | 0.69 | ITGB3 (0.36) | ITGB3ITGAVITGB1ITGA2BITGA5 | |
| SCHEMBL7010312 | 0.69 | ITGB3 (0.43) | ITGB3ITGAVKCNK3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413955-B1 | 1,8-NAPHTHYRIDINES OR 5-THIO-1,8-NAPHTHYRIDINES OR 5-OXO-1,8-NAPHTHYRIDINES; BONE RESORPTION, OSTEOPOROSIS, VASCULAR REST-ENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIO-GENESIS, ATHEROSCLEROSIS, INFLAMMATORY ARTHRITIS, CANCER | MERCK & CO., INC. | 2002-07-02 | — | — | US | disclosed |