Progesterone

Progesterone

SCHEMBL7671

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PGR

The experimentally established mechanism targets of Progesterone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR known ✓ P06401 3/20 1.00
CYP3A4 P08684 7/20 1.00
LMNA P02545 7/20 1.00
ALDH1A1 P00352 6/20 1.00
SMN1; SMN2 Q16637 6/20 1.00
MAPT P10636 5/20 1.00
SERPINA6 P08185 5/20 1.00
MAPK1 P28482 4/20 1.00
TSHR P16473 4/20 1.00
SHBG P04278 4/20 1.00
NR3C1 P04150 3/20 1.00
AR P10275 3/20 1.00
GPBAR1 Q8TDU6 3/20 1.00
SIGMAR1 Q99720 3/20 1.00
NR3C2 P08235 3/20 1.00
CYP2C9 P11712 2/20 1.00
HIF1A Q16665 2/20 1.00
ABCB11 O95342 2/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Progesterone SCHEMBL8430168 1.00 CYP3A4 (1.00) CYP3A4LMNAALDH1A1SMN1; SMN2MAPT
Progesterone SCHEMBL13259536 1.00 CYP3A4 (1.00) CYP3A4LMNAALDH1A1SMN1; SMN2MAPT
Progesterone SCHEMBL15224316 1.00 CYP3A4 (1.00) CYP3A4LMNAALDH1A1SMN1; SMN2MAPT
Progesterone SCHEMBL20342397 1.00 CYP3A4 (1.00) CYP3A4LMNAALDH1A1SMN1; SMN2MAPT
Progesterone SCHEMBL3932110 1.00 CYP3A4 (1.00) CYP3A4LMNAALDH1A1SMN1; SMN2MAPT
Progesterone SCHEMBL23568915 1.00 CYP3A4 (1.00) CYP3A4LMNAALDH1A1SMN1; SMN2MAPT
Progesterone SCHEMBL12090497 1.00 CYP3A4 (1.00) CYP3A4LMNAALDH1A1SMN1; SMN2MAPT
Progesterone SCHEMBL17750737 1.00 CYP3A4 (1.00) CYP3A4LMNAALDH1A1SMN1; SMN2MAPT
Progesterone SCHEMBL20409003 1.00 CYP3A4 (1.00) CYP3A4LMNAALDH1A1SMN1; SMN2MAPT
Progesterone SCHEMBL14848937 1.00 CYP3A4 (1.00) CYP3A4LMNAALDH1A1SMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 184543 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6432632-B1 None US claimed
US-20260146967-A1 DEVICE AND SENSOR FOR DETECTION OF AN ANALYTE REMINDED, INC. (US) 2026-05-28 US claimed
EP-4747358-A1 METHOD AND DEVICE FOR SPERM SELECTION Adelaide University (AU) 2026-05-27 EP claimed
EP-4747643-A1 DEVICES AND METHODS FOR IMMUNOASSAY ANALYSIS OF BIOLOGICAL SAMPLES Vital Biosciences Inc. (CA) 2026-05-27 EP claimed
EP-4746850-A1 EXTENDED RELEASE DRUG-LOADED MICROPARTICLES Ferring BV (NL) 2026-05-27 EP claimed
CN-122094663-A Composition comprising progesterone and uses thereof 2026-05-26 CN claimed
CN-122094676-A Organic compound 2026-05-26 CN claimed
CN-122094677-A Organic compound 2026-05-26 CN claimed
US-20260137698-A1 CYCLIN-DEPENDENT KINASE 7 INHIBITORS JOINT STOCK CO «BIOCAD» (RU) 2026-05-21 US claimed
US-20260137680-A1 NOVEL COMPOUNDS SITRYX THERAPEUTICS LTD (GB) 2026-05-21 US claimed
US-4016250-A BY SELECTIVELY BINDING HORMONE CORNELL RESEARCH FOUNDATION, INC. (US) 1977-04-05 US claimed
US-4014987-A VAGINAL DEVICE; USING A HYDROPHOBIC POLYCARBOXYLIC ACID AS DRUG RELEASE RATE CONTROLLER ALZA CORPORATION (US) 1977-03-29 US claimed
US-4014988-A Method for treating hypermenorrhea with uterine therapeutic system ALZA CORPORATION (US) 1977-03-29 US claimed
US-4007211-A OXIDATIVE DECARBOXYLATION WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1977-02-08 US claimed
US-4006227-A MONTANOA TOMENTOSA EXTRACT GALLEGOS ALFRED J 1977-02-01 US claimed
US-3993072-A Microporous drug delivery device ALZA CORPORATION (US) 1976-11-23 US claimed
US-3967618-A Drug delivery device ALZA CORPORATION (US) 1976-07-06 US claimed
US-3960757-A HYDROPHOBIC TOYO JOZO CO., LTD. (JA) 1976-06-01 US claimed
US-3948262-A Novel drug delivery device ALZA CORPORATION (US) 1976-04-06 US claimed
US-3946106-A POLYSILOXANES G. D. SEARLE & CO. (US) 1976-03-23 US claimed