Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Progesterone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | SERPINA6 | P08185 | 5/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | SHBG | P04278 | 4/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 3/20 | 1.00 |
| ▸ | AR | P10275 | 3/20 | 1.00 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 1.00 |
| ▸ | NR3C2 | P08235 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Progesterone SCHEMBL3931579 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL15493962 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL16305628 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL14546167 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL13752811 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL23568915 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL418975 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL9120521 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL6661427 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL20342344 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230044183-A1 | PURIFICATION METHOD OF PROGESTERONE | ZHEJIANG SHENZHOU PHARMACEUTICAL COMPANY LTD (CN) | 2023-02-09 | — | — | US | disclosed |
| WO-2022195627-A1 | PROCESS FOR THE PREPARATION OF ALFAXALONE | RESPECT LABS LLP (IN) | 2022-09-22 | — | — | WO | disclosed |
| US-11360105-B2 | Method of evaluating adrenal steroids in saliva collected by cotton swab | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2022-06-14 | — | — | US | disclosed |
| US-20220153776-A1 | ANTAGONISTS OF CB1 RECEPTOR | INST NAT SANTE RECH MED (FR) | 2022-05-19 | — | — | US | disclosed |
| WO-2022074001-A1 | MEANS AND METHODS FOR THE CONVERSION OF ESTRADIOL TO 15ALPHA-HYDROXYESTRADIOL | MITHRA RECHERCHE ET DÉVELOPPEMENT SA (BE) | 2022-04-14 | — | — | WO | disclosed |
| WO-2021238312-A1 | METHOD FOR PURIFYING PROGESTERONE | 浙江神洲药业有限公司 | 2021-12-02 | — | — | WO | disclosed |
| EP-3212800-B1 | 21-HYDROXYLATION OF STEROIDS | SANOFI SA (FR) | 2021-09-15 | — | — | EP | disclosed |
| WO-2021012671-A1 | HIGHLY EFFICIENT PREPARATION METHOD FOR PROGESTERONE WITH LOW POLLUTION | 浙江神洲药业有限公司 | 2021-01-28 | — | — | WO | disclosed |
| US-10716795-B2 | Steroid analogues for neuroprotection | EMORY UNIVERSITY (US) | 2020-07-21 | — | — | US | disclosed |
| US-20200199170-A1 | COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITY | UNIV DEGLI STUDI DI FERRARA (IT) | 2020-06-25 | — | — | US | disclosed |
| EP-2251346-A2 | Process for preparing guggulsterones and guggulsterol | Seoul National University Industry Foundation (KR) | 2010-11-17 | — | — | EP | disclosed |
| US-20100273759-A1 | PROGESTERONE ANTAGONISTS | EVESTRA, INC. | 2010-10-28 | — | — | US | disclosed |
| WO-2010088409-A2 | METHODS OF NEUROPROTECTION USING NEUROPROTECTIVE STEROIDS AND A VITAMIN D | EMORY UNIVERSITY (US) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010075286-A1 | MOLECULAR ACTIVATORS OF THE Wnt/β-CATENIN PATHWAY | UNIVERSITY OF WASHINGTON (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20100120736-A1 | Mineralocorticoid Receptor Antagonists | N.V. ORGANON | 2010-05-13 | — | — | US | disclosed |
| WO-2009108804-A2 | STEROID ANALOGUES FOR NEUROPROTECTION | EMORY UNIVERSITY (US) | 2009-09-03 | — | — | WO | disclosed |
| EP-1265927-B1 | CRYSTAL | BAYER SCHERING PHARMA AG (DE) | 2009-04-29 | — | — | EP | disclosed |
| US-20070117221-A1 | Dielectrophoretic controlled scat hormone immunoassay apparatus and method | KNOWMTECH, LLC | 2007-05-24 | — | — | US | disclosed |
| US-20070055072-A1 | Process for preparing guggulsterones and guggulsterol | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2007-03-08 | — | — | US | disclosed |
| US-20070055072-A1 | Process for preparing guggulsterones and guggulsterol | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199170-A1 | COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITY | LPO, C5, MPO | PGR 3606/4885CYP3A4 585/4885LMNA 4203/4885 |
| US-20230044183-A1 | PURIFICATION METHOD OF PROGESTERONE | PGR, HSD17B7, NR5A1 | PGR 1/4885CYP3A4 463/4885LMNA 4628/4885 |
| US-20100273759-A1 | PROGESTERONE ANTAGONISTS | PGR, PGRMC2, PGRMC1 | PGR 1/4885CYP3A4 1069/4885LMNA 2912/4885 |
| US-10716795-B2 | Steroid analogues for neuroprotection | CYP11A1, NR3C2, HSD17B7 | PGR 276/4885CYP3A4 1956/4885LMNA 831/4885 |
| US-20220153776-A1 | ANTAGONISTS OF CB1 RECEPTOR | CNR2, CNR1, GPR18 | PGR 520/4885CYP3A4 3073/4885LMNA 4593/4885 |
| US-20070055072-A1 | Process for preparing guggulsterones and guggulsterol | CYP17A1, CYP46A1, HSD17B7 | PGR 101/4885CYP3A4 103/4885LMNA 1297/4885 |
| US-20100120736-A1 | Mineralocorticoid Receptor Antagonists | NR3C2, AGTR1, AGTR2 | PGR 301/4885CYP3A4 1753/4885LMNA 1513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.