SCHEMBL7671124

SCHEMBL7671124

CCCCc1nc2ccc(C(=O)C(C)C)cc2n1Cc1ccccc1Cl

nearest known ligand 0.57

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 8/20 0.54
AGTR2 P50052 8/20 0.54
KDM4E B2RXH2 1/20 0.52
ALDH1A1 P00352 1/20 0.52
LMNA P02545 1/20 0.52
HPGD P15428 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
TDP1 Q9NUW8 1/20 0.49
TP53 P04637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6170161 0.90 AGTR1 (0.66) AGTR1AGTR2KDM4EALDH1A1LMNA
SCHEMBL7670036 0.89 AGTR1 (0.57) AGTR1AGTR2KDM4EALDH1A1LMNA
SCHEMBL7675595 0.87 AGTR1 (0.53) AGTR1AGTR2KDM4EALDH1A1LMNA
SCHEMBL7676720 0.87 TDP1 (0.55) AGTR1AGTR2KDM4EALDH1A1LMNA
SCHEMBL169971 0.86 KDM4E (0.53) AGTR1AGTR2KDM4EALDH1A1LMNA
SCHEMBL6169187 0.83 AGTR1 (0.52) AGTR1AGTR2KDM4EALDH1A1LMNA
SCHEMBL6170375 0.83 AGTR1 (0.62) AGTR1AGTR2TDP1TP53
SCHEMBL7671121 0.83 AGTR1 (0.54) AGTR1AGTR2KDM4EALDH1A1HPGD
SCHEMBL7671757 0.83 TP53 (0.59) AGTR1AGTR2TDP1TP53
SCHEMBL7676367 0.83 AGTR1 (0.49) AGTR1AGTR2KDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6352985-B1 CARDIOVASCULAR DISORDERS OR GASTROINTESTINAL DISORDERS, DIABETES (TYPE II DIABETES), DIABETIC COMPLICATIONS METHOD FOR LOWERING THE BLOOD SUGAR LEVEL OF A PATIENT, FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-03-05 US disclosed
EP-1132087-A1 REMEDIES FOR POLYCYSTIC OVARY SYNDROME FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-09-12 EP disclosed
US-6166219-A Benzimidazole derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-12-26 US disclosed
EP-0882718-A1 BENZIMIDAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-12-09 EP disclosed