Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6709375 | 0.92 | ALDH1A1 (0.73) | ALDH1A1CYP3A4IDH1MIFKDM4E | |
| SCHEMBL7671543 | 0.85 | ALDH1A1 (0.63) | ALDH1A1CYP3A4IDH1MIFKDM4E | |
| SCHEMBL801397 | 0.85 | ALDH1A1 (0.63) | ALDH1A1CYP3A4IDH1MIFKDM4E | |
| SCHEMBL16154053 | 0.85 | ALDH1A1 (0.63) | ALDH1A1CYP3A4IDH1MIFKDM4E | |
| SCHEMBL31160231 | 0.84 | ALDH1A1 (0.61) | ALDH1A1CYP3A4IDH1MIFKDM4E | |
| SCHEMBL27664520 | 0.84 | ALDH1A1 (0.61) | ALDH1A1CYP3A4IDH1MIFCA2 | |
| SCHEMBL27312515 | 0.84 | ALDH1A1 (0.61) | ALDH1A1CYP3A4IDH1MIFKDM4E | |
| SCHEMBL990642 | 0.84 | ALDH1A1 (0.61) | ALDH1A1CYP3A4IDH1MIFKDM4E | |
| SCHEMBL20083591 | 0.84 | ALDH1A1 (0.61) | ALDH1A1CYP3A4IDH1MIFKDM4E | |
| SCHEMBL2385123 | 0.83 | ALDH1A1 (0.66) | ALDH1A1CYP3A4IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |