Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.56 |
| ▸ | XDH | P47989 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2343363 | 0.81 | XDH (0.65) | GDAXDH | |
| SCHEMBL10421282 | 0.79 | XDH (0.70) | GDAXDH | |
| SCHEMBL1767753 | 0.79 | XDH (0.66) | GDAXDH | |
| SCHEMBL2113442 | 0.78 | XDH (0.57) | GDAXDH | |
| SCHEMBL874738 | 0.76 | XDH (0.74) | GDAXDH | |
| SCHEMBL9960821 | 0.76 | XDH (0.69) | GDAXDH | |
| SCHEMBL5935074 | 0.76 | XDH (0.78) | GDAXDH | |
| SCHEMBL5048196 | 0.76 | GDA (0.62) | GDAXDH | |
| SCHEMBL3512361 | 0.76 | XDH (0.55) | GDAXDH | |
| SCHEMBL8864963 | 0.75 | XDH (0.54) | GDAXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691307-A | ANTITUMOR AGENTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-11-25 | — | — | US | claimed |
| CN-101214220-A | Sustained-release injection containing amethopterin synergist | JINAN SHUAIHUA MEDICAL TECHNOL (CN) | 2008-07-09 | — | — | CN | disclosed |
| CN-101011352-A | Anti-cancer composition loading both mtrosourea medicament and guanopterin analog | JINAN SHUAIHUA PHARM TECHNOLOG (CN) | 2007-08-08 | — | — | CN | disclosed |
| US-6436945-B2 | FOR ENHANCING THE CHEMOTHERAPEUTIC TREATMENT OF TUMOR CELLS IN A MAMMAL WITH AN ANTINEOPLASTIC ALKYLATING AGENT, WHICH CAUSES CYTOTOXIC LESIONS AT THE O6-POSITION OF GUANINE; O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE (AGT) INACTIVATOR | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE OF HEALTH AND HUMAN SERVICES | 2002-08-20 | — | — | US | disclosed |
| US-6333331-B1 | USEFUL IN INACTIVATING THE HUMAN DNA REPAIR PROTEIN O.SUP.6 -ALKYLGUANINE-DNA ALKYLTRANSFERASE; ANTICANCER AGENTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2001-12-25 | — | — | US | disclosed |
| EP-0775142-A1 | SUBSTITUTED O6 -BENZYLGUANINES AND 6(4)-BENZYLOXYPYRIMIDINES | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004281-A1 | SUBSTITUTED O6-BENZYLGUANINES AND 6(4)-BENZYLOXYPYRIMIDINES | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-02-15 | — | — | WO | disclosed |
| EP-0523160-A1 | CARBO-NUCLEOSIDE DERIVATIVES | FROUD, Clive (GB) | 1993-01-20 | — | — | EP | disclosed |
| WO-1991015488-A1 | CARBO-NUCLEOSIDE DERIVATIVES | FROUD, CLIVE (GB) | 1991-10-17 | — | — | WO | disclosed |