Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | ADH1B | P00325 | 3/20 | 0.61 |
| ▸ | ADH1A | P07327 | 3/20 | 0.61 |
| ▸ | ADH7 | P40394 | 3/20 | 0.61 |
| ▸ | ADH1C | P00326 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | FAAH | O00519 | 2/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | ADH4 | P08319 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031672 | 0.95 | TSHR (0.71) | TSHRADH1BADH1AADH7ADH1C | |
| SCHEMBL25093248 | 0.93 | TSHR (0.76) | TSHRADH1BADH1AADH7ADH1C | |
| SCHEMBL25274699 | 0.93 | TSHR (0.76) | TSHRADH1BADH1AADH7ADH1C | |
| SCHEMBL25093179 | 0.93 | TSHR (0.76) | TSHRADH1BADH1AADH7ADH1C | |
| SCHEMBL3022776 | 0.93 | TSHR (0.76) | TSHRADH1BADH1AADH7ADH1C | |
| SCHEMBL3030508 | 0.92 | TSHR (0.65) | TSHRADH1BADH1AADH7ADH1C | |
| SCHEMBL7678763 | 0.90 | TSHR (0.56) | TSHRADH1BADH1AADH7ADH1C | |
| SCHEMBL23929281 | 0.88 | TSHR (0.68) | TSHRADH1BADH1AADH7ADH1C | |
| SCHEMBL25200621 | 0.88 | TSHR (0.68) | TSHRADH1BADH1AADH7ADH1C | |
| SCHEMBL25124085 | 0.88 | TSHR (0.61) | TSHRADH1BADH1AADH7ADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380197-B1 | FOR TREATING AND PREVENTING A PLETHORA OF DISEASES INCLUDING DIABETES | AVENTIS PHARMA S. A. (FR) | 2002-04-30 | — | — | US | claimed |
| EP-1001943-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | claimed |
| WO-1999003843-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | claimed |
| US-6380197-B1 | FOR TREATING AND PREVENTING A PLETHORA OF DISEASES INCLUDING DIABETES | AVENTIS PHARMA S. A. (FR) | 2002-04-30 | — | — | US | disclosed |
| EP-1001943-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999003843-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | disclosed |