Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.60 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.55 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.53 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198766 | 0.87 | AGTR1 (0.79) | AGTR1AGTR2DRD2TBXA2RTLR7 | |
| SCHEMBL9122418 | 0.86 | AGTR1 (0.58) | AGTR1AGTR2DRD2TBXA2RTLR7 | |
| SCHEMBL9087920 | 0.85 | AGTR1 (0.76) | AGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL9198925 | 0.85 | AGTR1 (0.78) | AGTR1AGTR2DRD2TBXA2RTLR7 | |
| SCHEMBL6169805 | 0.85 | PPARG (0.56) | AGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL9275378 | 0.84 | AGTR1 (0.78) | AGTR1AGTR2DRD2TBXA2RTLR7 | |
| SCHEMBL6171210 | 0.84 | AGTR1 (0.62) | AGTR1AGTR2 | |
| SCHEMBL6170958 | 0.83 | AGTR1 (0.62) | AGTR1AGTR2 | |
| SCHEMBL8393751 | 0.83 | AGTR1 (0.73) | AGTR1AGTR2 | |
| SCHEMBL169971 | 0.82 | KDM4E (0.53) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6352985-B1 | CARDIOVASCULAR DISORDERS OR GASTROINTESTINAL DISORDERS, DIABETES (TYPE II DIABETES), DIABETIC COMPLICATIONS METHOD FOR LOWERING THE BLOOD SUGAR LEVEL OF A PATIENT, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| EP-1132087-A1 | REMEDIES FOR POLYCYSTIC OVARY SYNDROME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-12 | — | — | EP | disclosed |
| US-6166219-A | Benzimidazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0882718-A1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |