Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | APP | P05067 | 6/20 | 0.51 |
| ▸ | SNCA | P37840 | 6/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673568 | 1.00 | MAPT (0.51) | MAPTAPPSNCAHCRTR1ERBB2 | |
| SCHEMBL7679531 | 0.77 | TRPA1 (0.50) | MAPTAPPSNCAHCRTR1ERBB2 | |
| SCHEMBL7679532 | 0.77 | TRPA1 (0.50) | MAPTAPPSNCAHCRTR1ERBB2 | |
| SCHEMBL7671094 | 0.77 | MAPT (0.56) | MAPTAPPSNCAHCRTR1ERBB2 | |
| SCHEMBL7671087 | 0.77 | MAPT (0.56) | MAPTAPPSNCAHCRTR1ERBB2 | |
| SCHEMBL7678889 | 0.76 | APP (0.75) | MAPTAPPSNCAHCRTR1ERBB2 | |
| SCHEMBL7678890 | 0.76 | APP (0.75) | MAPTAPPSNCAHCRTR1ERBB2 | |
| SCHEMBL7679502 | 0.75 | APP (0.54) | MAPTAPPSNCAHCRTR1ERBB2 | |
| SCHEMBL7678762 | 0.75 | APP (0.54) | MAPTAPPSNCAHCRTR1ERBB2 | |
| SCHEMBL7678759 | 0.75 | APP (0.54) | MAPTAPPSNCAHCRTR1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | OSI PHARMACEUTICALS, INC. | 2002-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | TP53, MYC, VHL | MAPT 2381/4885APP 4305/4885SNCA 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.