Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 20/20 | 0.67 |
| ▸ | HTR1B | P28222 | 20/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 20/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 20/20 | 0.67 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672258 | 0.97 | HTR1A (0.71) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7665897 | 0.88 | HTR1A (0.75) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7672277 | 0.88 | HTR1A (0.71) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7676350 | 0.87 | HTR1A (0.70) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7666014 | 0.87 | HTR1A (0.62) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7673544 | 0.86 | HTR1A (0.72) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7668347 | 0.85 | HTR1A (0.58) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7677080 | 0.85 | HTR1A (0.74) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7001148 | 0.84 | HTR1A (0.72) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7672508 | 0.84 | HTR1A (0.79) | HTR1AADRA1DHTR1BADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355647-B1 | INHIBIT THE SEROTONIN REUPTAKE. HYPERPROLACTINEMIA, VASOSPASMS, HYPERTENSION, GASTROINTESTINAL DISORDERS ASSOCIATED WITH MOTILITY AND SECRETION | ABBOTT LABORATORIES | 2002-03-12 | — | — | US | disclosed |