Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 20/20 | 0.82 |
| ▸ | MMP9 | P14780 | 15/20 | 0.82 |
| ▸ | MMP3 | P08254 | 13/20 | 0.82 |
| ▸ | MMP7 | P09237 | 11/20 | 0.82 |
| ▸ | MMP13 | P45452 | 12/20 | 0.64 |
| ▸ | MMP12 | P39900 | 1/20 | 0.61 |
| ▸ | MMP2 | P08253 | 4/20 | 0.59 |
| ▸ | MMP8 | P22894 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077683 | 0.91 | MMP1 (1.00) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7683951 | 0.86 | MMP1 (0.74) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7509736 | 0.85 | MMP1 (1.00) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL11933919 | 0.81 | MMP1 (0.90) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7349862 | 0.80 | MMP1 (0.91) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7763139 | 0.79 | MMP1 (0.98) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7533064 | 0.78 | MMP1 (0.91) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7533059 | 0.78 | MMP1 (0.91) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL6981692 | 0.78 | MMP1 (1.00) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7393667 | 0.78 | MMP1 (1.00) | MMP1MMP9MMP3MMP7MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465474-B1 | TREATMENT OF SUCH AS OSTEOARTHITIS, RHEUMATOID ARTHRITIS, PREVENTION OR ARREST OF TUMOR GROWTH AND METASTASIS, CORNEAL ULCERATION, LACK OF CORNEAL HEALING, MACULAR DEGENERATION, PERIODONTAL DISEASE, GINGIVITIS | THE PROCTER & GAMBLE COMPANY | 2002-10-15 | — | — | US | disclosed |
| US-6150370-A | 1,3-DINITROCYCLIC COMPOUND TREATS NUMEROUS DISEASES CAUSED BY UNDESIRED METALLOPROTEASE ACTIVITY, SUCH AS TUMOR METASTASIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, SKIN INFLAMMATION, ULCERATIONS, AND PERIODONTITIS | THE PROCTER & GAMBLE COMPANY (US) | 2000-11-21 | — | — | US | disclosed |