SCHEMBL7674368

SCHEMBL7674368

CCCCN(CCCC)C(CC)Oc1ccc(-c2nc3ccccn3c2C)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
KDM4E B2RXH2 2/20 0.49
MAPT P10636 1/20 0.49
HRH3 Q9Y5N1 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.39
ALDH1A1 P00352 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
TUBB4A P04350 1/20 0.39
TUBB P07437 1/20 0.39
TUBA3C P0DPH7 1/20 0.39
TUBA1B P68363 1/20 0.39
TUBA4A P68366 1/20 0.39
TUBB4B P68371 1/20 0.39
TUBB3 Q13509 1/20 0.39
TUBB2A Q13885 1/20 0.39
TUBB8 Q3ZCM7 1/20 0.39
TUBA3E Q6PEY2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10569536 0.87 HRH3 (0.42) NPC1RAB9AKDM4EMAPTHRH3
SCHEMBL7677823 0.84 HRH3 (0.67) NPC1RAB9AKDM4EMAPTHRH3
SCHEMBL10569049 0.84 HRH3 (0.42) NPC1RAB9AKDM4EMAPTHRH3
SCHEMBL10569141 0.83 HRH3 (0.54) HRH3
SCHEMBL7318458 0.80 HRH3 (0.42) MAPTHRH3
SCHEMBL7674373 0.80 HRH3 (0.72) NPC1RAB9AKDM4EMAPTHRH3
Hydrochloric Acid SCHEMBL7321620 0.80 HRH3 (0.41) MAPTHRH3
SCHEMBL10569504 0.80 HRH3 (0.51) HRH3CYP1A2CYP2C9CYP2C19MAPK1
SCHEMBL7689909 0.78 HRH3 (0.43) MAPTHRH3
SCHEMBL7681802 0.78 HRH3 (0.67) NPC1RAB9AKDM4EMAPTHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6489337-B1 TREATMENT OF ALZHEIMER'S DISEASE, EPILEPSY, EATING DISORDERS, LEARNING AND MEMORY DISORDERS, MIGRAINE, SLEEP/WAKE DISORDERS, ALLERGIC RHINITIS, SCHIZOPHRENIA, MILD COGNITIVE IMPAIRMENT, AND ASTHMA ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-12-03 US disclosed
US-4871745-A LOCAL ANESTHETICS ORTHO PHARMACEUTICAL CORPORATION (US) 1989-10-03 US disclosed
US-4833149-A ANTISECRETORY AGENTS, CALCIUM CHANNEL BLOCKERS ORTHO PHARMACEUTICAL CORPORATION (US) 1989-05-23 US disclosed
US-4791117-A LOCAL ANTESTHETICS, ANTISECRETORY AGENTS ORTHO PHARMACEUTICAL CORPORATION (US) 1988-12-13 US disclosed
US-4727145-A LOCAL ANESTHETICS ORTHO PHARMACEUTICAL CORPORATION (US) 1988-02-23 US disclosed