Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 11/20 | 0.53 |
| ▸ | FNTB | P49356 | 11/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | HRAS | P01112 | 1/20 | 0.43 |
| ▸ | KRAS | P01116 | 1/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5787316 | 0.93 | FNTA (0.59) | FNTAFNTBPSEN1PSEN2APH1B | |
| SCHEMBL5787326 | 0.93 | FNTA (0.59) | FNTAFNTBPSEN1PSEN2APH1B | |
| SCHEMBL6615448 | 0.91 | FNTA (0.53) | FNTAFNTBPSEN1PSEN2APH1B | |
| SCHEMBL6615441 | 0.91 | FNTA (0.53) | FNTAFNTBPSEN1PSEN2APH1B | |
| SCHEMBL5791085 | 0.90 | FNTA (0.59) | FNTAFNTBPSEN1PSEN2APH1B | |
| SCHEMBL5791079 | 0.90 | FNTA (0.59) | FNTAFNTBPSEN1PSEN2APH1B | |
| SCHEMBL6639321 | 0.90 | FNTA (0.51) | FNTAFNTBPSEN1PSEN2APH1B | |
| SCHEMBL6634461 | 0.88 | FNTA (0.49) | FNTAFNTBPSEN1PSEN2APH1B | |
| SCHEMBL6614927 | 0.88 | FNTA (0.49) | FNTAFNTBPSEN1PSEN2APH1B | |
| SCHEMBL5755209 | 0.87 | FNTA (0.53) | FNTAFNTBPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458783-B1 | INHIBITION OF FARNESYL TRANSFERASE, WHICH IS AN ENZYME INVOLVED IN RAS ONCOGENE EXPRESSION, IS EFFECTED BY COMPOUNDS OF THE FORMULAS OF BENODIAZEPINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-01 | — | — | US | disclosed |
| WO-2001081322-A1 | NON-IMIDAZOLE BENZODIAZEPINE INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-01 | — | — | WO | disclosed |