Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 8/20 | 0.59 |
| ▸ | FNTB | P49356 | 8/20 | 0.59 |
| ▸ | HRAS | P01112 | 1/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP7 | P09237 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791079 | 1.00 | FNTA (0.59) | FNTAFNTBHRASKRASPGGT1B | |
| SCHEMBL5787326 | 0.91 | FNTA (0.59) | FNTAFNTBHRASKRASPGGT1B | |
| SCHEMBL5787316 | 0.91 | FNTA (0.59) | FNTAFNTBHRASKRASPGGT1B | |
| SCHEMBL7674549 | 0.90 | FNTA (0.53) | FNTAFNTBHRASKRASPGGT1B | |
| SCHEMBL6615448 | 0.88 | FNTA (0.53) | FNTAFNTBHRASKRASPGGT1B | |
| SCHEMBL6615441 | 0.88 | FNTA (0.53) | FNTAFNTBHRASKRASPGGT1B | |
| SCHEMBL6639321 | 0.88 | FNTA (0.51) | FNTAFNTBHRASKRASPGGT1B | |
| SCHEMBL6634461 | 0.85 | FNTA (0.49) | FNTAFNTBHRASKRASPGGT1B | |
| SCHEMBL6614927 | 0.85 | FNTA (0.49) | FNTAFNTBHRASKRASPGGT1B | |
| SCHEMBL5755209 | 0.85 | FNTA (0.53) | FNTAFNTBHRASKRASPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074921-B2 | Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds | BRISTOL MYERS SQUIBB COMPANY (US) | 2006-07-11 | — | — | US | claimed |
| EP-1443936-A4 | PROCESS FOR THE PREPARATION OF 3,7-DISUBSTITUTED-2,3,4,5- TETRAHYDRO-1H-1,4-BENZODIAZEPINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2006-01-11 | — | — | EP | claimed |
| EP-1443936-A2 | PROCESS FOR THE PREPARATION OF 3,7-DISUBSTITUTED-2,3,4,5- TETRAHYDRO-1H-1,4-BENZODIAZEPINE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2004-08-11 | — | — | EP | claimed |
| US-20030162965-A1 | Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds | BRISTOL-MYERS SQUIBB COMPANY | 2003-08-28 | — | — | US | claimed |
| WO-2003041658-A2 | PROCESS FOR THE PREPARATION OF 3,7-DISUBSTITUTED-2,3,4,5- TETRAHYDRO-1H-1,4-BENZODIAZEPINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-05-22 | — | — | WO | claimed |
| US-7074921-B2 | Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds | BRISTOL MYERS SQUIBB COMPANY (US) | 2006-07-11 | — | — | US | disclosed |
| US-20030162965-A1 | Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds | BRISTOL-MYERS SQUIBB COMPANY | 2003-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162965-A1 | Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds | GABRA4, GABRA3, GABRA6 | FNTA 43/4885FNTB 27/4885HRAS 3246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.