SCHEMBL7675962

SCHEMBL7675962

CC(Cc1c[nH]c2ccccc12)C(=O)NC1CCCCC1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 2/20 0.63
MMP9 P14780 2/20 0.63
MMP8 P22894 2/20 0.63
POLB P06746 3/20 0.60
MAPT P10636 3/20 0.60
RECQL P46063 2/20 0.60
KDM4E B2RXH2 2/20 0.60
APAF1 O14727 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
HDAC3 O15379 2/20 0.57
HDAC4 P56524 2/20 0.57
HDAC1 Q13547 2/20 0.57
HDAC7 Q8WUI4 2/20 0.57
HDAC2 Q92769 2/20 0.57
HDAC10 Q969S8 2/20 0.57
HDAC11 Q96DB2 2/20 0.57
HDAC8 Q9BY41 2/20 0.57
HDAC6 Q9UBN7 2/20 0.57
HDAC9 Q9UKV0 2/20 0.57
HDAC5 Q9UQL6 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7671751 0.86 NMBR (0.67) MMP2MMP9MMP8POLBMAPT
SCHEMBL7854930 0.86 POLB (0.60) MMP2MMP9MMP8POLBMAPT
SCHEMBL7646131 0.86 SOS1 (0.75) MMP2MMP9MMP8POLBMAPT
SCHEMBL27798635 0.86 SOS1 (0.75) MMP2MMP9MMP8POLBMAPT
SCHEMBL9825896 0.86 SOS1 (0.75) MMP2MMP9MMP8POLBMAPT
SCHEMBL7671985 0.84 NMBR (0.65) MMP2MMP9MMP8POLBMAPT
SCHEMBL7674666 0.82 BCHE (0.71) POLBMAPTRECQLKDM4EAPAF1
SCHEMBL28799370 0.82 SOS1 (0.56) MMP2MMP9MMP8POLBMAPT
SCHEMBL28799369 0.82 SOS1 (0.56) MMP2MMP9MMP8POLBMAPT
SCHEMBL7854107 0.81 KDM4E (0.70) MMP9MMP8POLBMAPTRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6472418-B1 Non-peptide NK1 receptors antagonists WARNER-LAMBERT COMPANY 2002-10-29 US disclosed
EP-1140914-A1 NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS WARNER-LAMBERT COMPANY (US) 2001-10-10 EP disclosed
WO-2000037462-A1 NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS WARNER-LAMBERT COMPANY (US) 2000-06-29 WO disclosed