Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573594 | 0.91 | PTPN1 (0.49) | PTPN1TACR1MBTPS1MAPTPOLB | |
| SCHEMBL4650261 | 0.90 | PTPN1 (0.51) | PTPN1TACR1MBTPS1MAPTPOLB | |
| SCHEMBL7240680 | 0.89 | PTPN1 (0.47) | PTPN1TACR1MBTPS1MAPTPOLB | |
| SCHEMBL7240686 | 0.89 | PTPN1 (0.47) | PTPN1TACR1MBTPS1MAPTPOLB | |
| SCHEMBL7239314 | 0.88 | TACR1 (0.48) | PTPN1TACR1MBTPS1MAPTPOLB | |
| SCHEMBL7239303 | 0.88 | TACR1 (0.48) | PTPN1TACR1MBTPS1MAPTPOLB | |
| SCHEMBL7241770 | 0.86 | TACR1 (0.46) | PTPN1TACR1MBTPS1MAPTPOLB | |
| SCHEMBL7672421 | 0.86 | PTPN1 (0.58) | PTPN1MBTPS1KLK5CTSSCTSB | |
| SCHEMBL7249306 | 0.86 | TACR1 (0.46) | PTPN1TACR1MBTPS1MAPTPOLB | |
| SCHEMBL7678618 | 0.86 | TACR1 (0.50) | PTPN1TACR1MAPTPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410585-B1 | THERAPY FOR NON-INSULIN DEPEND DIABETES | BIOVITRUM AB (SE) | 2002-06-25 | — | — | US | disclosed |
| EP-1161421-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | Pharmacia & Upjohn Aktiebolag (SE) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000053583-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2000-09-14 | — | — | WO | disclosed |