Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 19/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 19/20 | 0.63 |
| ▸ | HTR1B | P28222 | 19/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 19/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 19/20 | 0.63 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3458036 | 0.93 | HTR1A (0.73) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL6834969 | 0.93 | HTR1A (0.72) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7722154 | 0.90 | HTR1A (0.68) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6992140 | 0.89 | HTR1A (0.56) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7715000 | 0.89 | HTR1A (0.66) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7720143 | 0.89 | HTR1A (0.62) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7715064 | 0.89 | HTR1A (0.66) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7719566 | 0.88 | HTR1A (0.65) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7722203 | 0.87 | HTR1A (0.60) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7532906 | 0.87 | HTR1A (0.58) | HTR1AADRA1DHTR1BADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387912-B1 | STROKE THERAPY | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6355647-B1 | INHIBIT THE SEROTONIN REUPTAKE. HYPERPROLACTINEMIA, VASOSPASMS, HYPERTENSION, GASTROINTESTINAL DISORDERS ASSOCIATED WITH MOTILITY AND SECRETION | ABBOTT LABORATORIES | 2002-03-12 | — | — | US | disclosed |