Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672935 | 0.90 | ACHE (0.52) | ACHEOPRM1SLC22A1CHRM2SLC6A4 | |
| SCHEMBL8198310 | 0.90 | ACHE (0.49) | ACHEOPRM1SLC22A1CHRM2SLC6A4 | |
| SCHEMBL7679182 | 0.89 | ACHE (0.51) | ACHEOPRM1SLC22A1CHRM2SLC6A4 | |
| SCHEMBL7674153 | 0.87 | ACHE (0.49) | ACHEOPRM1SLC22A1CHRM2SLC6A4 | |
| SCHEMBL7674403 | 0.86 | ACHE (0.48) | ACHEOPRM1SLC22A1CHRM2SLC6A4 | |
| SCHEMBL7190137 | 0.86 | ACHE (0.55) | ACHEOPRM1SLC22A1CHRM2SLC6A4 | |
| SCHEMBL7672213 | 0.86 | ACHE (0.55) | ACHEOPRM1SLC22A1CHRM2SLC6A4 | |
| SCHEMBL7568003 | 0.86 | ACHE (0.55) | ACHEOPRM1SLC22A1CHRM2SLC6A4 | |
| SCHEMBL7671597 | 0.83 | ACHE (0.45) | ACHEOPRM1SLC22A1CHRM2SLC6A4 | |
| Trifluoroacetic Acid SCHEMBL7677598 | 0.81 | ACHE (0.43) | ACHEOPRM1SLC22A1CHRM2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020037888-A1 | 4-imidazol-1-ylmethyl-2-(2-(2-oxo-piperidin-1-yl)-phenoxy) -benzonitrile for example; farnesyl-protein transferase inhibitors; treating cancer, benign proliferative disorder, hepatitis virus, restenosis, and polycystic kidney disease | MERCK & CO., INC. | 2002-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037888-A1 | 4-imidazol-1-ylmethyl-2-(2-(2-oxo-piperidin-1-yl)-phenoxy) -benzonitrile for example; farnesyl-protein transferase inhibitors; treating cancer, benign proliferative disorder, hepatitis virus, restenosis, and polycystic kidney disease | FNTA, PKD1, FNTB | ACHE 4845/4885OPRM1 3148/4885SLC22A1 3199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.