Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.77 |
| ▸ | RAB9A | P51151 | 2/20 | 0.77 |
| ▸ | BLM | P54132 | 2/20 | 0.77 |
| ▸ | RECQL | P46063 | 2/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.75 |
| ▸ | MEN1 | O00255 | 4/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.75 |
| ▸ | GLA | P06280 | 3/20 | 0.75 |
| ▸ | TP53 | P04637 | 2/20 | 0.75 |
| ▸ | HPGD | P15428 | 2/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | HBB | P68871 | 2/20 | 0.75 |
| ▸ | STAT6 | P42226 | 1/20 | 0.75 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.75 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324984 | 0.90 | TOP1 (0.78) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL6232779 | 0.90 | TOP1 (0.77) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL27540723 | 0.90 | TOP1 (0.77) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL8486195 | 0.90 | TOP1 (0.76) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL27547279 | 0.90 | TOP1 (0.76) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL7263268 | 0.90 | TOP1 (0.75) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL7627096 | 0.90 | TOP1 (0.75) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL6849474 | 0.88 | TOP1 (0.78) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL7626519 | 0.88 | TOP1 (0.72) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL7635279 | 0.88 | TOP1 (0.72) | TOP1KDM4ERAB9ABLMRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101376659-A | Method for purifying camptothecine and derivative thereof | SHANGHAI NORTHCAROLINA CHEMLAB (CN) | 2009-03-04 | — | — | CN | claimed |
| CN-101376659-B | Method for purifying camptothecine and derivative thereof | SHANGHAI BIOCOMPOUNDS CHEMLAB CO., LTD. (CN) | 2011-11-30 | — | — | CN | disclosed |
| CN-101376659-A | Method for purifying camptothecine and derivative thereof | SHANGHAI NORTHCAROLINA CHEMLAB (CN) | 2009-03-04 | — | — | CN | disclosed |
| US-6403603-B1 | ANTITUMOR AGENT | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-06-11 | — | — | US | disclosed |
| WO-2000066127-A1 | NOVEL HIGHLY LIPOPHILIC CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2000-11-09 | — | — | WO | disclosed |
| CN-1048296-C | Preparation method of 9-amino camptothecin | PHARMACIA & UPJOHN SPA (IT) | 2000-01-12 | — | — | CN | disclosed |
| CN-1222523-A | Process for preparation of 9-amino camptothecin | PHARMACIA & UPJOHN SPA (IT) | 1999-07-14 | — | — | CN | disclosed |
| CN-1113384-A | Preparation method of 9-amino camptothecin | PHARMACIA SPA (IT) | 1995-12-13 | — | — | CN | disclosed |