Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.77 |
| ▸ | GLA | P06280 | 3/20 | 0.77 |
| ▸ | RECQL | P46063 | 2/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.76 |
| ▸ | TP53 | P04637 | 2/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | HBB | P68871 | 2/20 | 0.76 |
| ▸ | RAB9A | P51151 | 2/20 | 0.76 |
| ▸ | BLM | P54132 | 2/20 | 0.76 |
| ▸ | STAT6 | P42226 | 1/20 | 0.76 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.76 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.76 |
| ▸ | GMNN | O75496 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27540723 | 1.00 | TOP1 (0.77) | TOP1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8486195 | 0.91 | TOP1 (0.76) | TOP1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27547279 | 0.91 | TOP1 (0.76) | TOP1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8324984 | 0.91 | TOP1 (0.78) | TOP1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7677097 | 0.90 | TOP1 (0.77) | TOP1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7263268 | 0.90 | TOP1 (0.75) | TOP1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7627096 | 0.90 | TOP1 (0.75) | TOP1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7635279 | 0.89 | TOP1 (0.72) | TOP1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6367280 | 0.89 | TOP1 (0.78) | TOP1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6849474 | 0.89 | TOP1 (0.78) | TOP1ALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61085389-A | — | — | None | — | — | JP | disclosed |
| EP-1551371-A2 | STABILIZED NANOPARTICLE FORMULATIONS OF CAMPTOTHECA DERIVATIVES | Imarx Therapeutics, Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-0963988-B1 | Intermediates for making camptothecin and camptothecin analogs | UNIV NORTH CAROLINA STATE (US) | 2005-04-27 | — | — | EP | disclosed |
| WO-2005007136-A1 | METHODS OF MAKING PHARMACEUTICAL FORMULATIONS FOR THE DELIVERY OF DRUGS HAVING LOW AQUEOUS SOLUBILITY | IMARX THERAPEUTICS, INC. (US) | 2005-01-27 | — | — | WO | disclosed |
| US-20040247624-A1 | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility | IMARX THERAPEUTICS, INC. | 2004-12-09 | — | — | US | disclosed |
| US-20040009229-A1 | Stabilized nanoparticle formulations of camptotheca derivatives | IMARX THERAPEUTICS, INC. | 2004-01-15 | — | — | US | disclosed |
| WO-2003103596-A2 | STABILIZED NANOPARTICLE FORMULATIONS OF CAMPTOTHECA DERIVATIVES | IMARX THERAPEUTICS, INC. (US) | 2003-12-18 | — | — | WO | disclosed |
| US-20030059465-A1 | Stabilized nanoparticle formulations of camptotheca derivatives | IMARX THERAPEUTICS, INC. | 2003-03-27 | — | — | US | disclosed |
| EP-0982307-B1 | 9 -Amino- and 9-nitro-camptothecin derivatives, process for their preparation and use as antitumor agents | PHARMACIA ITALIA SPA (IT) | 2002-12-04 | — | — | EP | disclosed |
| EP-0694035-B1 | WATER-SOLUBLE CAMPTOTHECIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2002-07-17 | — | — | EP | disclosed |
| US-5254690-A | Alkoxymethylpyridine d-ring intermediates useful for the synthesis of camptpthecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-10-19 | — | — | US | disclosed |
| US-5247089-A | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-09-21 | — | — | US | disclosed |
| US-5243050-A | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-09-07 | — | — | US | disclosed |
| US-5212317-A | Methods and intermediates for the assymmetric synthesis of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-05-18 | — | — | US | disclosed |
| US-5200524-A | Camptothecin intermediates and method of making same | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-04-06 | — | — | US | disclosed |
| US-5191082-A | Camptothecin intermediate and method of making camptothecin intermediates | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-03-02 | — | — | US | disclosed |
| US-5162532-A | INTERMEDIATES AND METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1992-11-10 | — | — | US | disclosed |
| WO-1992011263-A1 | METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1992-07-09 | — | — | WO | disclosed |
| JP-S6185389-A | NOVEL CAMPTOTHECIN DERIVATIVE | YAKULT HONSHA CO LTD | 1986-04-30 | — | — | JP | disclosed |
| JP-S06185389-A | — | — | 0001-01-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030059465-A1 | Stabilized nanoparticle formulations of camptotheca derivatives | PDE8A, LPXN, TOP2A | TOP1 5/4885ALDH1A1 1817/4885MEN1 817/4885 |
| US-20040009229-A1 | Stabilized nanoparticle formulations of camptotheca derivatives | PDE8A, LPXN, TOP2A | TOP1 5/4885ALDH1A1 1817/4885MEN1 817/4885 |
| US-20040247624-A1 | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility | ACR, LPXN, ABCG2 | TOP1 499/4885ALDH1A1 853/4885MEN1 2352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.