Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.50 |
| ▸ | NCOR1 | O75376 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5100599 | 0.94 | CAMKK2 (0.54) | HDAC1CAMKK2HDAC3NCOR1HDAC2 | |
| SCHEMBL5099819 | 0.93 | HDAC1 (0.56) | HDAC1CAMKK2HDAC3NCOR1HDAC2 | |
| SCHEMBL5100716 | 0.84 | CAMKK2 (0.50) | HDAC1CAMKK2GSK3BMKNK1MAPK8 | |
| SCHEMBL5094681 | 0.83 | MAPK8 (0.54) | HDAC1CAMKK2HDAC3NCOR1HDAC2 | |
| SCHEMBL5091711 | 0.82 | MAPK8 (0.55) | HDAC1CAMKK2HDAC3NCOR1HDAC2 | |
| SCHEMBL5100280 | 0.81 | HDAC1 (0.53) | HDAC1CAMKK2HDAC3NCOR1HDAC2 | |
| SCHEMBL5091408 | 0.81 | CAMKK2 (0.54) | HDAC1CAMKK2HDAC3NCOR1HDAC2 | |
| SCHEMBL5092092 | 0.79 | CLK4 (0.69) | HDAC1CAMKK2HDAC3NCOR1HDAC2 | |
| SCHEMBL5091615 | 0.79 | HDAC1 (0.54) | HDAC1CAMKK2HDAC3NCOR1HDAC2 | |
| SCHEMBL5089488 | 0.79 | CAMKK2 (0.61) | HDAC1CAMKK2HDAC3NCOR1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417185-B1 | HETEROCYCLIC ENZYME INHIBITORS | CHIRON CORPORATION | 2002-07-09 | — | — | US | disclosed |