Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 6/20 | 1.00 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.83 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.83 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.83 |
| ▸ | PPARG | P37231 | 2/20 | 0.83 |
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | PTGES | O14684 | 1/20 | 0.83 |
| ▸ | XPO1 | O14980 | 1/20 | 0.83 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.83 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.83 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.83 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.83 |
| ▸ | EGFR | P00533 | 1/20 | 0.83 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.83 |
| ▸ | PGR | P06401 | 1/20 | 0.83 |
| ▸ | POLB | P06746 | 1/20 | 0.83 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.83 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.83 |
| ▸ | MAPT | P10636 | 1/20 | 0.83 |
| ▸ | RARB | P10826 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7682572 | 0.94 | PLA2G4A (0.89) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL7682381 | 0.93 | PLA2G4A (0.87) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL8423162 | 0.93 | PLA2G4A (0.87) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL7677234 | 0.91 | PLA2G4A (0.83) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL7676209 | 0.91 | PLA2G4A (0.83) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL8119691 | 0.91 | PLA2G4A (0.83) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| Zafirlukast SCHEMBL4175 | 0.91 | PLA2G4A (1.00) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| Zafirlukast SCHEMBL30885065 | 0.91 | PLA2G4A (1.00) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| Zafirlukast SCHEMBL6600322 | 0.91 | PLA2G4A (1.00) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| Zafirlukast SCHEMBL29861631 | 0.91 | PLA2G4A (1.00) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500853-B1 | ENZYME INHIBITORS SUCH AS 4-((1-BENZHYDRYL-5-(((BUTYLAMINO)-CARBONYL)AMINO)-1H-INDOL-3-YL)METHYL)-3 -METHOXYBENZOIC ACID USED AS ANTIINFLAMMATORY AGENTS FOR PROPHYLAXIS OF ARTHRITIS, INFLAMMATORY BOWEL DISEASE OR ASTHMA | GENETICS INSTITUTE, LLC | 2002-12-31 | — | — | US | disclosed |