Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHKA | P35790 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927234 | 0.83 | HRH3 (0.43) | KDM4ENCF1PRMT6ALDH1A1SMN1; SMN2 | |
| SCHEMBL4778748 | 0.81 | HRH3 (0.47) | KDM4EALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL7672750 | 0.70 | MC4R (0.48) | MC4RKDM4ETDP1LMNACHKA | |
| SCHEMBL26041063 | 0.68 | MC4R (0.46) | MC4RKDM4ETDP1LMNACHKA | |
| SCHEMBL1449845 | 0.68 | MC4R (0.55) | MC4RKDM4ELMNACHKAALDH1A1 | |
| SCHEMBL21177108 | 0.66 | MC4R (0.47) | MC4RKDM4ETDP1LMNACHKA | |
| SCHEMBL12536025 | 0.66 | CYP2D6 (0.54) | MC4RKDM4ETDP1LMNAALDH1A1 | |
| SCHEMBL12359436 | 0.66 | MC4R (0.56) | MC4RKDM4ETDP1LMNACHKA | |
| SCHEMBL467306 | 0.65 | — | — | |
| SCHEMBL2972644 | 0.64 | MC4R (0.46) | MC4RKDM4ETDP1LMNACHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |