Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL380504 | 0.83 | HDAC1 (0.47) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| SCHEMBL380775 | 0.82 | HDAC3 (0.46) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| SCHEMBL380427 | 0.81 | HDAC6 (0.42) | HDAC1HDAC3HDAC6 | |
| SCHEMBL25253452 | 0.79 | HDAC1 (0.56) | HDAC1HDAC3HDAC6NCOR2HDAC2 | |
| SCHEMBL8280051 | 0.79 | HDAC1 (0.47) | HDAC1HDAC3HDAC6HDAC4PDK2 | |
| SCHEMBL768201 | 0.78 | HDAC6 (0.44) | HDAC1HDAC3HDAC6 | |
| SCHEMBL13575595 | 0.74 | HPGD (0.56) | HDAC1HDAC3HDAC6 | |
| SCHEMBL379907 | 0.72 | HDAC6 (0.42) | HDAC6 | |
| SCHEMBL381354 | 0.72 | HDAC6 (0.43) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| SCHEMBL356994 | 0.72 | HDAC1 (0.56) | HDAC1HDAC6PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476253-B2 | Amide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20120071467-A1 | AMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071467-A1 | AMIDE DERIVATIVE | CHRM3, CHRM2, TACR2 | HDAC1 414/4885HDAC3 202/4885HDAC6 407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.