Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.72 |
| ▸ | SMO | Q99835 | 1/20 | 0.61 |
| ▸ | RAF1 | P04049 | 2/20 | 0.59 |
| ▸ | BRAF | P15056 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838866 | 0.92 | MAPK14 (0.65) | MAPK14RAF1BRAF | |
| SCHEMBL6485519 | 0.89 | MAPK14 (0.89) | MAPK14SMORAF1BRAFMAPT | |
| SCHEMBL6978618 | 0.86 | MAPK14 (0.65) | MAPK14RAF1BRAF | |
| SCHEMBL7678484 | 0.86 | MAPK14 (0.69) | MAPK14SMORAF1BRAF | |
| SCHEMBL2968436 | 0.85 | MAPK14 (0.82) | MAPK14SMORAF1BRAFMAPT | |
| SCHEMBL6969088 | 0.84 | MAPK14 (0.61) | MAPK14SMO | |
| SCHEMBL7807977 | 0.84 | MAPK14 (0.78) | MAPK14SMORAF1BRAFMAPT | |
| SCHEMBL6969309 | 0.84 | MAPK14 (0.62) | MAPK14RAF1BRAF | |
| SCHEMBL6477445 | 0.83 | MAPK14 (1.00) | MAPK14SMORAF1BRAFMAPT | |
| SCHEMBL6968243 | 0.82 | MAPK14 (0.61) | MAPK14RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| EP-1115707-A1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018738-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |