Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.78 |
| ▸ | SMO | Q99835 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6485519 | 0.93 | MAPK14 (0.89) | MAPK14SMOMAPTKMT2AUSP2 | |
| SCHEMBL7807923 | 0.93 | MAPK14 (0.85) | MAPK14SMOMAPTKMT2AKDM4E | |
| SCHEMBL2968436 | 0.93 | MAPK14 (0.82) | MAPK14SMOMAPTKMT2AUSP2 | |
| SCHEMBL7846077 | 0.89 | MAPK14 (0.73) | MAPK14SMOMAPTKMT2AUSP2 | |
| SCHEMBL6477445 | 0.88 | MAPK14 (1.00) | MAPK14SMOMAPTKMT2AUSP2 | |
| SCHEMBL7780464 | 0.86 | MAPK14 (0.65) | MAPK14SMOMAPTHTT | |
| SCHEMBL7804593 | 0.85 | MAPK14 (0.58) | MAPK14SMOMAPTKMT2AMEN1 | |
| SCHEMBL7804619 | 0.85 | MAPK14 (0.57) | MAPK14SMOMAPTKMT2AMEN1 | |
| SCHEMBL7805605 | 0.84 | MAPK14 (0.61) | MAPK14SMOMAPTHTT | |
| SCHEMBL7679107 | 0.84 | MAPK14 (0.72) | MAPK14SMOMAPTKMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |