Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 17/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679255 | 1.00 | LSS (0.60) | LSSMEN1KMT2AADRB2ADRB1 | |
| SCHEMBL7767798 | 1.00 | LSS (0.60) | LSSMEN1KMT2AADRB2ADRB1 | |
| SCHEMBL7679251 | 1.00 | LSS (0.60) | LSSMEN1KMT2AADRB2ADRB1 | |
| Fumaric Acid SCHEMBL7682141 | 0.96 | LSS (0.56) | LSSMEN1KMT2A | |
| Fumaric Acid SCHEMBL7682131 | 0.96 | LSS (0.56) | LSSMEN1KMT2A | |
| SCHEMBL7682139 | 0.85 | LSS (0.55) | LSSMEN1KMT2A | |
| SCHEMBL7768122 | 0.84 | LSS (0.47) | LSSMEN1KMT2AKDM4EOPRK1 | |
| SCHEMBL7681955 | 0.84 | LSS (0.47) | LSSMEN1KMT2AKDM4EOPRK1 | |
| SCHEMBL7681964 | 0.84 | LSS (0.47) | LSSMEN1KMT2AKDM4EOPRK1 | |
| SCHEMBL7681960 | 0.84 | LSS (0.47) | LSSMEN1KMT2AKDM4EOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | claimed |
| EP-0778264-B1 | Tertiary amines having antimycotic and cholesterol lowering activity | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | claimed |
| EP-0778264-A1 | Tertiary amines having antimycotic and cholesterol lowering activity | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | claimed |
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-0778264-B1 | Tertiary amines having antimycotic and cholesterol lowering activity | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0778264-A1 | Tertiary amines having antimycotic and cholesterol lowering activity | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |