Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681081 | 0.99 | MAPT (0.46) | MAPTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL7679699 | 0.97 | MAPT (0.46) | MAPTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2430950 | 0.88 | MAPT (0.52) | MAPTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6881776 | 0.84 | ALDH1A1 (0.44) | MAPTRAB9AMAPK1AKR1C2ALDH1A1 | |
| SCHEMBL19371251 | 0.81 | ALDH1A1 (0.47) | MAPTLMNARAB9ANPC1MAPK1 | |
| SCHEMBL30813068 | 0.81 | ALDH1A1 (0.47) | MAPTLMNARAB9ANPC1MAPK1 | |
| SCHEMBL7683609 | 0.81 | ALDH1A1 (0.64) | MAPTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL19371262 | 0.81 | ALDH1A1 (0.46) | MAPTMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL1803059 | 0.80 | ALDH1A1 (0.67) | MAPTLMNASMN1; SMN2RAB9AMAPK1 | |
| SCHEMBL20596690 | 0.79 | ALDH1A1 (0.45) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469181-B1 | PREPARING 2-OXINDOLES AND N-HYROXY-2- OXINDOLES VIA REDUCTION OF 2-NITROARYLMALONATE DIESTERS WITHOUT ISOLATION OF INTERMEDIATES | CATALYTICA, INC. | 2002-10-22 | — | — | US | disclosed |
| EP-0809631-A4 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA INC (US) | 1998-07-08 | — | — | EP | disclosed |
| EP-0809631-A1 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA, INC. (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996023770-A1 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA, INC. (US) | 1996-08-08 | — | — | WO | disclosed |