Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680661 | 1.00 | ALDH1A1 (0.46) | ALDH1A1THRBKMT2AHPGDMAPT | |
| SCHEMBL7680665 | 1.00 | ALDH1A1 (0.46) | ALDH1A1THRBKMT2AHPGDMAPT | |
| SCHEMBL7974081 | 1.00 | ALDH1A1 (0.46) | ALDH1A1THRBKMT2AHPGDMAPT | |
| SCHEMBL1821265 | 0.89 | ALDH1A1 (0.46) | ALDH1A1THRBKMT2AHPGDMAPT | |
| SCHEMBL7680271 | 0.89 | ALDH1A1 (0.46) | ALDH1A1THRBKMT2AHPGDMAPT | |
| SCHEMBL1821268 | 0.89 | ALDH1A1 (0.46) | ALDH1A1THRBKMT2AHPGDMAPT | |
| SCHEMBL7680427 | 0.84 | ALDH1A1 (0.45) | ALDH1A1THRBKMT2AMAPTCYP3A4 | |
| SCHEMBL7680603 | 0.84 | ALDH1A1 (0.45) | ALDH1A1THRBKMT2AMAPTCYP3A4 | |
| SCHEMBL7680422 | 0.84 | ALDH1A1 (0.45) | ALDH1A1THRBKMT2AMAPTCYP3A4 | |
| SCHEMBL733757 | 0.84 | ALDH1A1 (0.51) | ALDH1A1KMT2AHPGDMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495693-B2 | TREATMENT OF ALZHEIMER'S DISEASE | ATHENA NEUROSCIENCES, INC. | 2002-12-17 | — | — | US | disclosed |